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We are fortunate to be living in a period of “oncology renaissance,” an era where major advances in science and medicine have culminated in an explosion of novel therapies that are decisively making meaningful differences to the lives of cancer patients. This is certainly true for cutaneous oncology, where advanced disease states such as metastatic melanoma can finally be met with a choice of drugs that can lead to a real survival benefit in patients for whom care was previously palliative. It is becoming increasingly apparent that the most effective care of advanced cutaneous oncology patients occurs through a multidisciplinary approach utilizing evidence-based national guidelines for best practice, which considers both tumor-specific and patient-specific factors. It is discernable that there is no “onesize- fits-all” approach for the care of cutaneous oncology patients, but instead, a range of potential therapeutic options and solutions. Patient management is dictated by a combination of medical and social considerations including nuances of the cancer in question, patient co morbidities, social circumstances, access to healthcare, immediate support network, and medical healthcare coverage. Thus, the final decision in the course of management becomes personalized to each patient.