دانلود کتاب روش‌های پیشرفته و مدل‌سازی ریاضی بیوفیلم

Biofilms are a complex and heterogeneous aggregation of microorganisms held together by their excreting extracellular polymer substances. Even though microorganisms can cause many serious issues, such as chronic infections, food contamination, and equipment corrosion, they can also be used constructively for things such as wastewater treatment, heavy metal removal from hazardous waste sites, biofuel production, and power generation through microbial fuel cells. Because of the great variety of biofilm applications, a lot of work has gone into figuring out how biofilms form and interact with their surroundings. However, biofilm growth and evolution are very complex interactions among physicochemical and biological processes. Considerable challenges exist in understanding microbial processes where macroscopic dynamics of nutrient transport must be coupled with microscopic bacteria growth and their elementary biochemical reactions at reactive or enzymatic interfaces, in addition to the microbiological and/or ecological aspects of the “micro” organisms involved in biofilms. Furthermore, biofilm processes’ intrinsic interdisciplinary character provides a platform for interdisciplinary research from a variety of fields, including biofouling, soil microbial ecology, bioremediation, wastewater engineering, tissue engineering, biosynthesis, and chronic infections. If we are to be able to link biofilm function to biotechnologies, this will allow scientists and engineers to redesign their devices or processes to inhibit harmful biofilms or to promote beneficial ones in clinical, environmental, or industrial applications. Hence, it is essential for understanding and controlling how bacteria interact with their environment and space and affect the production or degradation of a variety of compounds in an interdependent environment, such as nutrients, temperature, pH, and moisture. Mathematical models are critical to modern biotechnologydboth in research and in engineering practice. Thus, many models of biofilms have been developed to include various biofilm reactor modules. Modeling plays a similar function in 21st-century microbiology as the microscope did in previous centuries; it is undoubtedly the most essential study tool for examining complicated phenomena and processes in all sectors of biofilms, from individual cells to microbial community ecosystems. We believe that the mathematical model has a lot of potential in terms of furthering our understanding of how biofilms interact with their environments, as well as how they are transferred into biotechnologies and microbiome-based diagnostics and therapies.