The prevalence of clinically significant pituitary tumors is increasing (up to 1/1000 people) and comprises approximately 16% of all primary cranial neoplasms. Although the natural history of pituitary adenomas (PA) is not completely described, most microadenomas (lesions <10 mm) have a benign course, whereas macroadenomas (≥10 mm) require careful monitoring. Macroadenomas present a higher risk for hormonal abnormalities (either excess or deficits) and mass effects, including vision loss.
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