دانلود کتاب سرطان پانکراس – یک رویکرد چند رشته ای

Pancreatic cancer is a dreadful disease with an increasing impact on cancer-related mortality worldwide. This disease is the unfortunate exception to the general trend of improvement in cancer-related mortality. Pancreatic cancer is projected to become the second leading cause of cancer-related deaths worldwide by 2030. There is a significant need for better treatment options to improve the survival and quality of life of pancreatic cancer patients.

In the last decade, management of pancreatic cancer has shifted towards a multidisciplinary approach with encouraging results. There have been several recent advances, from screening high-risk cohorts to emerging precision medicine paradigms, as well as recently reported practice-changing data for surgically resected patients.

This book provides a comprehensive, state-of-the-art review of this field and will serve as a valuable resource for physicians and researchers with an interest in pancreatic cancer. The book describes data about risk factors and genetic predisposition for pancreatic cancer and highlights current screening strategies and preliminary results. The diagnosis and staging of pancreatic cancer is reviewed, with focus on imaging evaluations, laparoscopy, endo­scopic ultrasound-guided biopsies, and biomarkers. For locally advanced and metastatic disease, systemic therapy, radiation, and chemoradiation approaches are discussed. For resectable and borderline resectable disease, surgical management and perioperative therapy are reviewed.

Given the multimodality approach of pancreatic cancer, the role of gastro­enterologists in the management of the disease is reviewed with emphasis on screening, diagnosis, symptoms management, and endoscopic ultrasound-guided local therapies and fiducial markers placement. Emerging paradigms in pancreatic cancer management are presented, such as minimally invasive surgical approaches, local ablative technologies, emerging radiation approaches, image-based biomarkers, liquid biopsies, and molecular profil­ing of pancreatic cancer. This book also provides a valuable insight into nutri­tion and early integration of supportive/palliative care for pancreatic cancer patients.

This textbook will serve as a very useful resource for physicians and sci­entists dealing with, or interested in, this challenging malignancy. Given the multidisciplinary approach of pancreatic cancer, this book has brought together experts from a variety of integrated disciplines such as gastroenterol­ogy, medical oncology, surgical oncology, radiation oncology, pathology, radiology, rehabilitation medicine, and nutrition. The audience for this book includes medical oncologists, radiation oncologists, surgeons, gastroenterol­ogists, research scientists with interest in pancreatic cancer, fellows and resi­dents training in surgical, radiation, and medical oncology as well as gastroenterology.

All chapters are written by experts in their fields and include the most up-to-date scientific and clinical information. This comprehensive and yet con­cise state-of-the-art review of this field will help guide patient management and stimulate investigative efforts. This book outlines The MD Anderson Approach to managing pancreatic cancer, written mostly by experts from UT MD Anderson Cancer Center with some collaborative colleagues from other institutions. We are extremely grateful to all the contributors for their time and effort in this endeavor.