دانلود کتاب ایمونولوژی سلولی و مولکولی

This tenth edition of Cellular and Molecular Immunology includes substantial revisions, reflecting recent scientific advances and clinical applications of the science, while at the same time we have maintained the clear and readable style that has been typical of previous editions. Our presentation of new information focuses primarily on the important concepts and has not significantly increased the length of the book. We have also rewritten many sections for increased clarity, accuracy, and completeness. The field of immunology has moved beyond establishing fundamental principles of the mechanisms of immune responses to applying these principles to understand and develop therapies for human disease. The revolution in immunological therapies over the last 20 years has been extraordinary. It is especially satisfying for immunologists that some of the most innovative and effective immunotherapies have been developed because the basic science has matured and the complex mechanisms of immune activation and regulation have been elucidated in increasing detail. Nowhere has the link between basic science and clinical medicine been demonstrated more forcefully than in the development of new cancer immunotherapies. Throughout the book, we have paid special a ttention to the clinical relevance of immunology and the scientific underpinnings of human disease and therapies. As we write this preface, the SARS CoV-2 pandemic has spread throughout the entire world. The science of immunology is of critical importance to the way we confront this challenge, and immunologists are front and center in learning how the virus causes disease, how we can treat it, and how we can develop effective vaccines. In addition to these translational aspects of immunology, we have also updated basic concepts wherever there has been significant new understanding. Some examples of these fundamental advances include a be tter understanding of tissue resident macrophages and memory T cell subsets, mechanisms by which inflammasomes and nucleic acid sensors stimulate innate immune responses, the sequences of events in T cell–dependent antibody responses, and mechanisms by which tumor evasion of immune a ttack can be overcome